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Since different neuronal cell types are neatly organized into layers in the hippocampus, it has frequently been used as a model system for studying neurophysiology. in terms of its main cell types) similar to other cortical areas, which makes it a popular target for experimental studies.
Allen Cell Types Database. Physiological methods, while powerful for interrogating functional properties, are relatively low throughput, therefore making it difficult to determine the cell types comprising a circuit systematically and What makes the hippocampus special?
In the hippocampus, pyramidal cells (PCs) are not the only cell type sensitive to cholinergic stimulation. Its structure is significantly simpler than that of the neocortex, but it is also in many ways (e.g. Its structure is significantly simpler than that of the neocortex, but it is also in many ways (e.g. Brandt MD, Maass A, Kempermann G, Storch A (2010) Physical exercise increases notch activity, proliferation and cell cycle exit of type-3 progenitor cells in adult hippocampal neurogenesis. Given that the hippocampus is structurally simple and evolutionarily ancient, within-cell-type heterogeneity is likely to be a general and crucial feature of the mammalian brain. 1 A spatial atlas of inhibitory cell types in mouse hippocampus Xiaoyan Qian*1, Kenneth D. Harris*†2, Thomas Hauling1,2, Dimitris Nicoloutsopoulos2, Ana B. Muñoz-Manchado3, Nathan Skene2,3, Jens Hjerling-Leffler3, Mats Nilsson†1 1. The hippocampus serves a critical role in declarative memory—our capacity to recall everyday facts and events. 7A–C, E). As progenitor cell types reside in the adult hippocampus, altered rates of neurogenesis and gliogenesis, possibly influenced by seizures, are likely to be relevant to both histological alterations and clinical manifestations of this pathology.
I am not that familiar with the hippocampus but here are some genes that separates cortical excitatory cells: Fezf2, Ctip2, Otx1, Sox5, Tbr1, Couptf1, Bhlhb5, Satb2, Cux1/2, Lhx2 and Rorb.
Underneath, protein expression in each annotated cell type are reported using the same units. Hippocampus i On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). The hippocampus is an evolutionarily conserved, old cortical region. in terms of its main cell types) similar to other cortical areas, which makes it a popular target for experimental studies. We and others have identified heterogeneity in the population of pyramidal neurons projecting out of the hippocampus (Mizuseki et al., 2011; Graves et al., 2012).