Artemisinin-based combination therapy (ACT) has been first-line treatment for uncomplicated Plasmodium falciparum malaria globally for the past 10–15 years and has contributed greatly to a reduction of malaria illnesses and deaths during 2005–2015 (1,2).However, artemisinin resistance emerged in Cambodia during 2008, where it then spread and even developed de novo throughout the … After the discovery by Alphonse Laveran in 1880 that the causative agent for malaria was a parasite, detailed studies on …

1 Most patients were in the World Health Organization African region (92%) and South-East Asian region (5%). In 2017, an estimated 219 million cases of malaria and 435 000 malaria-related deaths occurred worldwide. Malaria, a mosquito-borne disease caused by Plasmodium species, is a severe and reemerging global health issue despite years of effort in global malaria control. Background: Chronic asymptomatic Plasmodium falciparum infections are common in endemic areas and are thought to contribute to the maintenance of malaria immunity. Understanding cellular and molecular interactions between host and parasites during an infection … Plasmodium falciparum Histidine-Rich Protein 2 and 3 Gene Deletions and Their Implications in Malaria Control by Josphat Nyataya 1 , John Waitumbi 1,* , Victor A. Mobegi 2 , Ayman Noreddin 3,4 and Mohamed E. El Zowalaty 3,5,* Tropical medicine has its share of wily microbes. Plasmodium falciparum: morphology, life cycle, pathogenesis and clinical disease. Plasmodium falciparum-resistance to sulphadoxine-pyrimethamine (SP) has been largely reported among pregnant women. Sickle cell trait has repeatedly been identified as a major human malaria resistance factor. The name ‘falciparum’ is derived by Welch from ‘falx’ meaning sickle or crescent and ‘parere’ meaning to bring forth. Children are highly susceptible to clinical malaria, and in regions where malaria is endemic, their immune systems must face successive encounters with Plasmodium falciparum parasites before they develop immunity, first against severe disease and later against uncomplicated malaria. For decades, doctors have used antimalarial drugs against P. falciparum. We multiplexed primer targets for Plasmodium genus and P. falciparum 18S rDNA in a single reaction, which we then amplified for 45 cycles. Among 4 species that human-pathogenic (P.falciparum, P.vivax, P.oval and P.malariae), P.falciparum is the most virulent as it is responsible for the majority of Malaria-caused deaths globally, especially in tropical and subtropical regions.It accounts for 80% of all human malarial infections and 90% of the deaths.


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